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Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
bevore 1970
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Old study with methodological deficiences.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Succinate, glycerophosphate and ascorbate as sources of cellular energy and as antiteratogens.
Author:
Landauer W., D. Sopher
Year:
1970
Bibliographic source:
J. Embryol. Exp. Morphol., 1970, 24(1), 187-202.
Reference Type:
secondary source
Title:
EVALUATION OF THE HEALTH ASPECTS OF SUCCINIC ACID AS A FOOD INGREDIENT
Author:
Jackson W.L.
Year:
1975
Bibliographic source:
NTIS (National Technical Information Service)

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The objective of this study was to investigate toxic or teratogenic effects in the embryos after Injection of sodium succinate hexahydrate into the yolk sacs of fertile hen eggs at 96 hours of incubation.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Sodium succinate hexahydrate
IUPAC Name:
Sodium succinate hexahydrate
Constituent 2
Reference substance name:
6106-21-4
Cas Number:
6106-21-4
IUPAC Name:
6106-21-4
Details on test material:
Name: sodium succinate hexahydrate

Test animals

Species:
other: hen eggs
Strain:
not specified

Administration / exposure

Details on exposure:
Injection of 7. 5 mg of sodium succinate hexahydrate into the yolk sacs of fertile hen eggs at 96 hours of incubation.

Results and discussion

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Any other information on results incl. tables

Injection of 7.5 mg of sodium succinate hexahydrate into the yolk sacs of fertile hen eggs at 96 hours of incubation produced no discernible toxic or teratogenic effects in the embryos.

Applicant's summary and conclusion

Conclusions:
Read across rationale: sodium succinate and succinic acid dissociate completely in low concentrations and are existent in solutions as the same ion.
Injection of 7.5 mg of sodium succinate hexahydrate into the yolk sacs of fertile hen eggs at 96 hours of incubation produced no discernible toxic or teratogenic effects in the embryos.
Executive summary:

Injection of 7.5 mg of sodium succinate hexahydrate into the yolk sacs of fertile hen eggs at 96 hours of incubation produced no discernible toxic or teratogenic effects in the embryos.