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EC number: 203-740-4
CAS number: 110-15-6
Monosodium succinate was dissolved in
distilled water and was administered orally via gavage to 5 groups of 4
male and 4 female rats each at doses of 0.5, 1, 2, 4 or 8 g per kg body
weight. The survivors were necropsied after 10 days.
No other clinical signs were noted than a
transient decrease in spontaneous activity of the animals at the highest
dose. One high dosed female died in week 1. Necropsy showed haemorrhage of
the lungs in some high dose group animals.
The LD50 was higher than 8000 mg monosodium succinate
per mg body weight. Even if the different molecular weights of monosodium
succinate and succinic acid are taken into account, the LD50 is far above
2000 mg per kg body weight and no classification is derived for succinic acid.
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