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EC number: 500-118-7 | CAS number: 52625-13-5 1 - 12.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
D-Glucitol propoxylated has been tested according to OECD 471 (Bacterial reverse mutation assay, 'AMES-test') and according to OECD 473 (Chromosome Aberration Test). Both studies were performed with and without metabolic activation.
Both test gave negative findings for genetic toxicity.
In all three in vitro assays, two by direct test and the third by ‘read across’ , as permitted by Annex XI paragraph 1.5, nominally from 2,2',2''-nitrilotriethanol, propoxylated; see report from Paul Illing Consultancy Services Ltd. and Marlin Consultancy (Illing and Barratt, 2009 and 2009). The report identifies that 2,2’,2’’-nitrilotriethanol, propoxylated is the most bioavailable of the NLP polyols linked by an ether group. Since appropriate read-across data are available, no further testing on D-glucitol propoxylated is warranted. For further details concerning the grouping, consult Illing and Barratt (2009 and 2009) in Section 13.
Short description of key information:
Three in vitro mutagenicity assays were all negative. Therefore
further testing is not required.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Findings from in-vitro genotoxicity testing do not warrant classification and labelling according to GHS (EU).
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