Registration Dossier
Registration Dossier
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EC number: 500-118-7 | CAS number: 52625-13-5 1 - 12.5 moles propoxylated
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 18, 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- D-Glucitol, propoxylated
- EC Number:
- 500-118-7
- EC Name:
- D-Glucitol, propoxylated
- Cas Number:
- 52625-13-5
- Molecular formula:
- (C3 H6 O)n (C3 H6 O)n (C3 H6 O)n (C3 H6 O)n (C3 H6 O)n (C3 H6 O)n C6 H14 O6 sum of n: >1 - <12.5 mol PO
- IUPAC Name:
- D-Glucitol, propoxylated
- Details on test material:
- sorbitol, propoxylated, (Mn = approx. 600 g/mol)
- Lot/batch No.: 95/0207PRP
- Analytical purity: not indicated by the sponsor; treated as 100 % pure
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Vehicle:
- water
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: No clinical signs of toxicity observed.
- Mortality:
- No mortality occured
- Clinical signs:
- other: no clinical signs were observed during the study
- Gross pathology:
- Necroscopy did not reveal any abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 is > 2000 mg/kg bw: No clinical signs of toxicity. No classification for acute oral toxicty according to EU criteria or GHS.
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