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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


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Administrative data

Description of key information

Rats were dosed five days per week for one year by gavage at a dose level of 300 mg/kg body weight.  HFC-143a was dissolved in corn oil.  They were held for an additional year  and sacrificed.  No treatment related tumors were found.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Dose descriptor:
300 mg/kg bw/day

Justification for classification or non-classification

HFC-143a did not show a carcinogenic response.

Additional information

Test article (HFC-143a) did not cause a carcinogenic response in this screening study. (Ref. Longstaff, E., Robinson, M., Bradbrook, C., Styles, JA., and Purchase, IFH., (1984). Genotoxicity and Carcinogenicity of fluorocarbons: Assessment by short-term in vitro tests and chronic exposures in rats. Toxicol. Appl. Pharmacol. 72, 15 -31.

Carcinogenicity: via oral route (target organ): other: all gross lesions and masses