Propane-1,2-diol, propoxylated

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1984

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data to permit interpretation of study results

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

no data

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tetrapropylene Glycol Crude

IUPAC Name:

Tetrapropylene Glycol Crude

Details on test material:

Name of test material (as cited in study report): Tetrapropylene Glycol Crude.
Molecular Formula: C12H26O5.
Molecular Weight: 250+.
Physical state: Black liquid.
Synonyms: Tripropylene Glycol Bottoms.
Reference: TB 840322-1216 A&B.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS:
Age at study initiation: 6-8 week old Sprague Dawley Rats.
Weight at study initiation: 280 - 427 g.
Fasting period before study: Overnight.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

not specified

Details on inhalation exposure:

1-hour exposure of 4 male rats to vapour of the test material generated at room temperature (calculated to contain 0.17 mg/L based on weight of sample before and after exposure).

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

1 h

Concentrations:

0.17 mg/L

No. of animals per sex per dose:

4 animals at the dose level of 0.17 mg/L

Control animals:

not specified

Details on study design:

Duration of observation period following administration: 14 days.
Frequency of observations and weighing: The animals were weighed before dosing, the day after dosing, and at 1 and 2 weeks after dosing. The animals were observed closely the day of treatment, then periodically for the 2-week observation period.
Necropsy of survivors performed: yes.
Other examinations performed: clinical signs, body weight.

Statistics:

none

Results and discussion

Preliminary study:

n/a

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

> 0.17 mg/L air

Based on:

test mat.

Mortality:

There was no mortality during the study.

Clinical signs:

other: There was no mortality during the study.

Body weight:

All rats gained body weight during the 2-week observation period.

Gross pathology:

No lesions attributable to administration of the test material were observed upon gross pathological examination 2 weeks post treatment.

Other findings:

none

Any other information on results incl. tables

none

Applicant's summary and conclusion

Interpretation of results:

other: The test was conducted on a very low concentration which is 0.17 mg/L, so Tetrapropylene Glycol Crude could not be classified for the inhalation end point based on this study report.

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

Under the testing conditions of this study, the acute inhalation LC50 of Tetrapropylene Glycol Crude is greater than 0.17 mg/L in Sprague Dawley
rats.  

Executive summary:

The test material, Tetrapropylene Glycol Crude, also known as Tripropylene Glycol Bottoms, was submitted for acute inhalation toxicological evaluation.

A 1-hour exposure of 4 male rats to vapour of the test material generated at room temperature (calculated to contain 0.17 mg/L based on weight of sample before and after exposure) resulted in no apparent adverse effects. There was no mortality during the study.

All rats appeared healthy and gained body weight during the 2-week observation period.

No lesions attributable to administration of the test material were observed upon gross pathological examination 2 weeks post treatment.

Under the testing conditions of this study, the acute inhalation LC50 of Tetrapropylene Glycol Crude is greater than 0.17 mg/L in Sprague Dawley rats.