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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data to permit interpretation of study results
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Tetrapropylene Glycol Crude
IUPAC Name:
Tetrapropylene Glycol Crude
Details on test material:
Name of test material (as cited in study report): Tetrapropylene Glycol Crude.
Molecular Formula: C12H26O5.
Molecular Weight: 250+.
Physical state: Black liquid.
Synonyms: Tripropylene Glycol Bottoms.
Reference: TB 840322-1216 A&B.

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS:
Age at study initiation: 6-8 week old Sprague Dawley Rats.
Weight at study initiation: 280 - 427 g.
Fasting period before study: Overnight.

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
1-hour exposure of 4 male rats to vapour of the test material generated at room temperature (calculated to contain 0.17 mg/L based on weight of sample before and after exposure).
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
0.17 mg/L
No. of animals per sex per dose:
4 animals at the dose level of 0.17 mg/L
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 14 days.
Frequency of observations and weighing: The animals were weighed before dosing, the day after dosing, and at 1 and 2 weeks after dosing. The animals were observed closely the day of treatment, then periodically for the 2-week observation period.
Necropsy of survivors performed: yes.
Other examinations performed: clinical signs, body weight.
Statistics:
none

Results and discussion

Preliminary study:
n/a
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 0.17 mg/L air
Based on:
test mat.
Mortality:
There was no mortality during the study.
Clinical signs:
other: There was no mortality during the study.
Body weight:
All rats gained body weight during the 2-week observation period.
Gross pathology:
No lesions attributable to administration of the test material were observed upon gross pathological examination 2 weeks post treatment.
Other findings:
none

Any other information on results incl. tables

none

Applicant's summary and conclusion

Interpretation of results:
other: The test was conducted on a very low concentration which is 0.17 mg/L, so Tetrapropylene Glycol Crude could not be classified for the inhalation end point based on this study report.
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Under the testing conditions of this study, the acute inhalation LC50 of Tetrapropylene Glycol Crude is greater than 0.17 mg/L in Sprague Dawley
rats.  
Executive summary:

The test material, Tetrapropylene Glycol Crude, also known as Tripropylene Glycol Bottoms, was submitted for acute inhalation toxicological evaluation.

A 1-hour exposure of 4 male rats to vapour of the test material generated at room temperature (calculated to contain 0.17 mg/L based on weight of sample before and after exposure) resulted in no apparent adverse effects. There was no mortality during the study.

All rats appeared healthy and gained body weight during the 2-week observation period.

No lesions attributable to administration of the test material were observed upon gross pathological examination 2 weeks post treatment.

Under the testing conditions of this study, the acute inhalation LC50 of Tetrapropylene Glycol Crude is greater than 0.17 mg/L in Sprague Dawley rats.