Registration Dossier
Registration Dossier
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EC number: 500-039-8 | CAS number: 25322-69-4 1 - 4.5 moles propoxylated
Endpoint summary
Administrative data
Description of key information
Additional information
96 hr LC50 (Danio rerio) >100 mg/l (limit dose). No effect observed.
48 hr EC50 (Daphnia magna) = 105.8 mg/l.
The 21d-NOEC to Daphnia magna with the structurally related substance D-Glucitol (Sorbitol), propoxylated (CAS# 52625-13-5) in a OECD 211 guideline study is = 10 mg/l (nominal) for all endpoints.
72 hr EC50 growth rate (Desmodesmus subspicatus ) > 100 mgl/l. No effects were observed.
3h-NOEC (activated sludge) = 1000 mg/L
Read-across statement
No-Longer-Polymer (NLP) polyether polyols are produced by the reaction of various starter molecules with propylene oxide and/or ethylene oxide. These substances exhibit a remarkable uniformity in the physical/chemical properties which influence their fate and distribution in the environment. All NLP polyols have a full acute aquatic ecotoxicity dataset and do not exhibit acute toxicity below 100 mg/L. However, differentiation in chronic invertebrate toxicity is apparent and is based on the alcohol- or amino- starter molecules used to prepare these NLP polyols. A sub-grouping based on (i) aliphatic alcohol and amine NLP polyols, (ii) EDA- (ethylenediamine) based amino NLP polyols and (iii) o-TDA- (orthodiaminotoluene) based aromatic NLP polyols is justified (ISOPA, 2010) and toxicity is expected to be similar between substances within each of these categories. It is considered appropriate to use ‘read-across’ of data of structural analogues within each sub-grouping to fill data gaps for chronic invertebrate toxicity and derive PNECs for endpoints based on these sub-groupings.
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