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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with national standard methods.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Propane-1,2-diol, propoxylated
EC Number:
500-039-8
EC Name:
Propane-1,2-diol, propoxylated
Cas Number:
25322-69-4
Molecular formula:
(C3 H6 O)n H2 O n= >1 - <4.5
IUPAC Name:
propane-1,2-diol, propoxylated
Details on test material:
Name: Propane-1,2-diol propoxylated
Molecular weight: Mn = 260 g/mole
Physical state: clear pale yellow liquid

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ORGANISMS: Rabbit New Zealand White
- Source: Hazelton Research Products, Denver, PA, USA
- Age: 8-12 weeks
- Weight at study initiation: 2.324-2.907 kg
- Group size: 5M+5F
- Controls: No

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
ADMINISTRATION: dermal
- Area covered: dorsal area of the trunk of the test animals
- Occlusion: occlusive 24 hour
- Vehicle: none
- Concentration in vehicle: undiluted
- Doses: 3000 mg/kg
- Removal of test substance: with gauze and water
Doses:
3000 mg/kg
No. of animals per sex per dose:
10
Details on study design:
Clinical observations daily, body weights recorded at day 7 and 14, gross necropsy carried out at termination.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Mortality:
No deaths occurred
Clinical signs:
other: None
Gross pathology:
Unremarkable
Other findings:
Erythema (grade 1) observed in 2/5 males and 2/5 females at 24 hours after application. All test sites were normal 48 hours after application.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal LD50 for this propoxylated propane-1,2-diol (molecular weight 230) was >3000 mg/kg. There were no clinical signs, transient erythema was observed in 4/10 rabbits. All animals were normal by 48 hours after application.