Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

specific investigations: other studies
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Read-across from analogue substance RDP, submitted on request of national CA regarding the endpoint neurotoxicity

Data source

Materials and methods

Type of method:
in vivo

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
RDP, analoque substance

Administration / exposure

Analytical verification of doses or concentrations:

Results and discussion

Details on results:
2000 mg/kg

NTE activity was minimal and no clinical signs of toxicity
were present.

5000 mg/kg

Delayed behavioral signs of neurotoxicity and
histomorphological changes in neural tissues were absent.

Based on the similarity of the structure of the substance
with the structures of structural analogues (Fyrolflex RDP
and TPP) and assuming that the double bond between oxygen
and phosphorus in TPP is stable, read across of
neurotoxicity data with Fyrolflex RDP is considered
acceptable. Therefore, there is no concern for workers with
regard to neurotoxicity.

Applicant's summary and conclusion

No neurotoxicuty to be expected based on read-across from analoque substance