Registration Dossier
Registration Dossier
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EC number: 234-319-3 | CAS number: 11097-59-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study was not performed according a specific guideline (e.g. no batch number or purity of the test substance is given and no independent repeated was performed) and it is not clear whether the study is performed according GLP principles. However, the conclusion is considered reliable and supported by a weight of evidence from analogue substance (P-93 and Alcamizer 5).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
- Principles of method if other than guideline:
- No specific quideline mentioned in the document.
- GLP compliance:
- not specified
- Type of assay:
- bacterial gene mutation assay
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Name (IUPAC): Hydrotalcite-like compound
Name (Usage, trade, etc.): DHT
Chemical formula: Mg3. 5~4. 5Al2(OH)1 1~1 3*CO3 2.5~3.5H2O
Constituent 1
Method
- Target gene:
- Base-pair substitutions:
TA100, TA1535, WP2uvrA
Frameshift:
TA98, TA1537, TA1538
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1538
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9mix
- Test concentrations with justification for top dose:
- 10, 50, 100, 500, 1000 en 5000 ug/plate
- Vehicle / solvent:
- Solvent control.
Controlsopen allclose all
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- N-ethyl-N-nitro-N-nitrosoguanidine
- Positive controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- benzo(a)pyrene
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
Results and discussion
Test results
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Negative
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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