Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973

Materials and methods

Principles of method if other than guideline:
other: acute dermal toxicity study
GLP compliance:
no
Test type:
other: acute dermal toxicity study

Test material

Constituent 1
Chemical structure
Reference substance name:
Di(benzothiazol-2-yl) disulphide
EC Number:
204-424-9
EC Name:
Di(benzothiazol-2-yl) disulphide
Cas Number:
120-78-5
Molecular formula:
C14H8N2S4
IUPAC Name:
di(benzothiazol-2-yl) disulphide
Details on test material:
CP 1612

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
corn oil
Duration of exposure:
24 h
Doses:
5010, 7940 mg/kg bw
No. of animals per sex per dose:
1 to 2 animal per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 7 940 mg/kg bw
Based on:
test mat.
Remarks on result:
other: clinical signs: reduced appetite and activity one two days

Any other information on results incl. tables

Mortality: no death occurred during the study

5010 mg/kg: male 0/1, female -, combined 0/1

7940 mg/kg: male 0/1, female 0/1, combined 0/2

Clinical signs observed: reduced appetite and activity (one to two days)

Gross autopsy (survivors 14 days study termination): viscera appeared normal

Applicant's summary and conclusion