Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-424-9 | CAS number: 120-78-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Ranking of allergic potency of rubber chemicals in a modified local lymph node assay
- Author:
- De Jong, W., H.; et al.
- Year:
- 2 002
- Bibliographic source:
- Toxicological Sciences 66, 226-232
Materials and methods
- Principles of method if other than guideline:
- Local lymph node assay (using ex vivo labeling of proliferating lymph node cells, according to Kimber and Weisberger 1989 Arch. Toxicol. 63, 274-282, Vanebriel et al 2000 Toxicol. Appl. Pharmacol 162, 77-85, Van Och et al. 2000 Toxicology 146, 49-59
- GLP compliance:
- no
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Di(benzothiazol-2-yl) disulphide
- EC Number:
- 204-424-9
- EC Name:
- Di(benzothiazol-2-yl) disulphide
- Cas Number:
- 120-78-5
- Molecular formula:
- C14H8N2S4
- IUPAC Name:
- di(benzothiazol-2-yl) disulphide
- Details on test material:
- MBTS, purity: 99%
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- no data
- No. of animals per dose:
- 3 per dose group, control 6
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: EC3: 2.9%
Any other information on results incl. tables
MBTS: EC3*: 2.9 % (L05 -L95: 1.4 - 6.7, estimated 90% confidence interval based on 200 bootstrap runs)
*effective concentration inducing a stimulation index of 3 in LLNA
Moderate skin sensitzing
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Executive summary:
The test substance MBTS is classified as skin sensitiser according regulation no. 1272/2008 (GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
