Registration Dossier
Registration Dossier
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EC number: 215-183-4 | CAS number: 1310-65-2
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: Case Reports
- Adequacy of study:
- supporting study
- Study period:
- 1982
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Data not sufficient for evaluation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Lithium-Induced Male Sexual Impaired: Two Case Reports
- Author:
- Blay, S.L. et al.
- Year:
- 1 982
- Bibliographic source:
- J. Clin. Psychiatry 43:497-498
Materials and methods
- Study type:
- health record, other
- Remarks:
- Case reports
- Endpoint addressed:
- toxicity to reproduction / fertility
Test guideline
- Qualifier:
- no guideline followed
Test material
- Reference substance name:
- Lithium carbonate
- EC Number:
- 209-062-5
- EC Name:
- Lithium carbonate
- Cas Number:
- 554-13-2
- Molecular formula:
- CH2O3.2Li
- IUPAC Name:
- dilithium carbonate
- Reference substance name:
- Lithium carbonate (case report 1)
- IUPAC Name:
- Lithium carbonate (case report 1)
- Reference substance name:
- Lithium compound not specified, most likely Li2CO3 (case report 2)
- IUPAC Name:
- Lithium compound not specified, most likely Li2CO3 (case report 2)
Constituent 1
Constituent 2
Constituent 3
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Two human case reports exist that led to the notion that lithium could impair male fertility. Male patients (n=2) under lithium therapy (serum levels 18-33 mg/L) complained about reduced libido sexualise and erectile dysfunction. After replacing the lithium by a placebo or after termination of lithium therapy, respectively, recovery of normal sexual functions was reported. This effect is however not surprising as lithium is a psychotropic drug. This effect is therefore not considered as toxic but most likely related secondary to the wished effect of lithium treatment.
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