Registration Dossier

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Lithium carbonate teratogenic effects in chick cardiomyocyte micromass system and mouse embryonic stem cell derived cardiomyocyte - Possible protective role of myo-inositol
Author:
W.M. Shaikh Qureshi, M.L Latif, T.L Parker, M.K. Pratten
Year:
2014
Bibliographic source:
Reproductive Toxicology 46 (2014) 106-114

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Lithium carbonate
EC Number:
209-062-5
EC Name:
Lithium carbonate
Cas Number:
554-13-2
Molecular formula:
CH2O3.2Li
IUPAC Name:
dilithium carbonate
Test material form:
solid

Results and discussion

Any other information on results incl. tables

In chick embryonic cardiomyocyte micromas system (MM) the lithium carbonate did not alter the toxicity estimation endpoints (contractile activity, cellular toxicity, cellular protein content, ROS), whereas in embryonic stem cell derived Cardiomyocyte (ESDC) system the cardiomyocytes contractile activity stopped at 1500 p.M and above with significant increase in total cellular protein contents.

Applicant's summary and conclusion

Executive summary:

Shaikh et al. (2014) evaluated the toxic effect of lithium carbonate in chick embryonic cardiomyocyte mircomass system (MM) and embryonic stem cell derived cardiomyocyte (ESDC), with possible protective role of myo-inositol. In chick embryonic cardiomyocyte micromas system (MM) the lithium carbonate did not alter the toxicity estimation endpoints (contractile activity, cellular toxicity, cellular protein content, ROS), whereas in embryonic stem cell derived Cardiomyocyte (ESDC) system the cardiomyocytes contractile activity stopped at 1500 µM and above with significant increase in total cellular protein contents.