Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-347-7 | CAS number: 16219-75-3
Endpoint summary
Administrative data
Description of key information
Available animal data indicate that ENB is an irritant to rabbit skin, and is very slightly irritating to the rabbit eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Occluded contact with 0.5 ml of undiluted ENB for 4 hrs produced mild to moderate erythema and edema on rabbit skin, which resolved by 7-14 days; necrosis was not seen. 0.1 ml of undiluted ENB instilled into the rabbit inferior conjunctival sac caused mild conjunctival hyperemia that resolved by 24-72 h post-instillation. With a volume of 0.01 ml, only slight conjunctival hyperemia developed within 1 h and resolved by 4h.
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
SKIN: From the available data, the level of skin irritation as measured by erythema indicates classification as a skin irritant is warranted. Individual animal data is not available to enable a definitive classification against the criteria in regulation 1272/2008. However, it is quite conceivable that 2 or the 3 animals would have produced more severe reactions and therefore a similar classification (category 2 skin irritant) under this regulation would seem appropriate.
EYE: Available evidence in animal studies indicates that ENB is not an irritant by EU general classification criteria, therefore, no classification is proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
