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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study conducted according to scientifically accepted method; old study with limited documentation.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not applicable
Remarks:
Study conducted 1974; limited documentation
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
EC Number:
500-051-3
EC Name:
1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
Cas Number:
26780-96-1
Molecular formula:
(C12H15N)x
IUPAC Name:
2,2,4-trimethyl-1,2-dihydroquinoline
Details on test material:
Flectol H; no further data on purity

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
water
Controls:
not required
Duration of treatment / exposure:
24 hours
Observation period:
4, 24, 48, 72 and 168 hours after treatment
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 4, 24, 48, 72 and 168 h
Score:
0
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 4, 24, 48, 72, 168 h
Score:
0
Max. score:
4
Reversibility:
fully reversible
Other effects:
No effects mentioned in report

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

The test compound was not irritating to the skin in an study equivalent to OECD TG 404 with 6 rabbits dosed with 500 mg TMQ.