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EC number: 260-754-3 | CAS number: 57472-68-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Oxybis(methyl-2,1-ethanediyl) diacrylate
- EC Number:
- 260-754-3
- EC Name:
- Oxybis(methyl-2,1-ethanediyl) diacrylate
- Cas Number:
- 57472-68-1
- Molecular formula:
- C12H18O5
- IUPAC Name:
- oxydipropane-1,2-diyl bisacrylate
- Details on test material:
- - Name of test material (as cited in study report): Dipropylenglykoldiacrylart
- Physical state: liquid
- Analytical purity: a detailed product characterization is included in the raw data
- Lot/batch No.: Partie 2/87
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 15 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: upper third of the back or flanks
- % coverage: application area: 2.5 cm x 2.5 cm
- Type of wrap if used: test patches were secured in position with a porous dressing (4 layers of absorbent gauze + porous bandage)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): at the end of the exposure period with lutrol and lutrol/water (1:1)
- Time after start of exposure: 4 hours
SCORING SYSTEM:
according to OECD guideline 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 15 days
- Remarks on result:
- other: scale was seen in 2/3 animals after 15 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
Any other information on results incl. tables
Table 1: Summary of dermal effects in rabbits after dorsal application of the test material for 4 h under semiocclusive conditions
|
Animal |
Erythema |
Edema score |
Further effects |
30-60 min after removal of the patches |
1 |
0 |
0 |
|
2 |
0 |
0 |
|
|
3 |
0 |
0 |
|
|
24 h after application |
1 |
2 |
0 |
overlapping erythema |
2 |
1 |
0 |
|
|
3 |
2 |
0 |
overlapping erythema |
|
48 h after application |
1 |
3 |
1 |
overlapping erythema and edema |
2 |
1 |
0 |
overlapping erythema |
|
3 |
3 |
1 |
overlapping erythema and edema |
|
72 h after application |
1 |
3 |
0 |
overlapping erythema |
2 |
2 |
0 |
overlapping erythema |
|
3 |
3 |
0 |
overlapping erythema |
|
8 days after application |
1 |
1 |
0 |
overlapping erythema and scale |
2 |
0 |
0 |
overlapping scale |
|
3 |
0 |
0 |
overlapping scale |
|
15 days after application |
1 |
0 |
0 |
scale |
2 |
0 |
0 |
|
|
3 |
0 |
0 |
scale |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- As the mean value of the erythema scores was 2.33, the substance is classified as irritating according to EU-criteria.
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