Registration Dossier
Registration Dossier
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EC number: 260-754-3 | CAS number: 57472-68-1
Neurotoxicity
Administrative data
Description of key information
Dermal:
Rat: subchronic 3 months: No neurotoxic effects were observed up to the highest dose tested in a dermal repeated dose toxicity study including evaluation of neurotoxicity (Bio/Dynamics Inc. 1992, Val. 2). Read-across to CAS No. 42978-66-5.
Key value for chemical safety assessment
Additional information
No neurotoxic effects were observed up to the highest dose tested in a 3 -months dermal repeated dose toxicity study including evaluation of neurotoxicity (Bio/Dynamics Inc. 1992, Val. 2) with the structurally related tripropylene glycol diacrylate (Cas No. 42978-66-5). The study is discussed in full detail in the repeated dose toxicity section.
Read across justification:
HDDA (CAS # 13048-33-4), DPGDA (CAS#57472-68-1) and TPGDA (CAS # 42978-66-5) are suitable for read across among each other as they are all structurally similar Difunctional Acrylates with comparable toxicological properties (all are sensitizing and have irritating effects on skin and eyes).
Justification for classification or non-classification
No classification for neurotoxicity is warranted as no neurotoxic effects were observed in a respective neurotoxicity study
with the structurally related tripropylene glycol diacrylate (Cas No. 42978-66-5).
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