Registration Dossier
Registration Dossier
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EC number: 222-059-3 | CAS number: 3332-27-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In the key study, performed according to OECD TG 203, Zebra fish (Danio rerio) were exposed to C14 AO under semi-static conditions for 96 hours. The 96-h LC50 was 2.4 mg AO/L.
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Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2.4 mg/L
Additional information
Two reliable studies are available for C14 AO. In the key study, performed according to OECD TG 203, Zebra fish (Danio rerio) were exposed to the substance under semi-static conditions for 96 hours at nominal concentrations of 0, 0.23, 0.46, 0.92, 1.84 or 3.68 mg AO/L [Mark UE (1992)]. The 96-h LC50 was 2.4 mg AO/L. In the supporting study, also performed according to OECD TG 203, Zebra fish were exposed to the substance at 0, 2.5 or 25 mg/L AO for 96 hours [Jung R (1987)]. The 96-h LC50 was between 2.5 and 25 mg AO/L.
Data are available also for C12-14 AO. These data may be used to support the findings of the studies performed using C14 AO alone as the substance contains a significant amount of C14 AO and the remainder comprises an analogue substance with very similar chain length.
There are four reliable studies available for the C12-14 amine oxide. Iwan GR et al (1975) exposed Fathead minnow (Pimephales promelas) to C12-14 AO under static conditions for 96 hours. The LC50 (96 h) based on nominal concentrations of amine oxide ranged from 2.67 to 3.46 mg AO/L depending on the source and pH of the water used. In a supporting study Bluegill (Lepomis macrochirus) were exposed to C12-14 AO under static conditions for 96 hours. The LC50 value was reported as 3.13 mg AO/L [Macek & Sleight (1972)]. Exposure of rainbow trout (Oncorhynchus mykiss) to C12-14 AO under static conditions for 96 hours resulted in a LC50 of 12.6 mg AO/L [Dommrose AM (1987)], whilst exposure of zebra fish (Danio rerio) to C12-14 AO under static conditions resulted in a 96 -h LC50 of 3 -30 mg AO/L [Hoechst AG (1987)].
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