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EC number: 629-776-4 | CAS number: 308065-15-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
The results of the chemical safety assessment do not indicate the need to investigate further the toxicity to sediment organisms
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity to sediment organisms is available for Fatty acids, C12-14 (even numbered), methyl ester (CAS No. 308065-15-8). Since the substance is readily biodegradable, chronic exposure of sediment organisms is unlikely. Furthermore, the substance is not toxic to aquatic organisms up to the limit of water solubility. In addition, available data indicate, that the test substance is not bioaccumulative. Based on the available information, toxicity to sediment organisms is not expected to be of concern.
Intrinsic properties and fate
All substances included in the SCAE Me category are readily biodegradable. According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological Sewage Treatment Plants (STPs) (ECHA 2008). Therefore, after passing through conventional STPs, only low concentrations of these substances are likely to be (if at all) released into the environment. Once present in the aquatic compartment further degradation will occur.
Aquatic ecotoxicity data
Aquatic short-term and long-term toxicity tests of the substance to fish, invertebrates, algae showed no adverse effects in the range of the water solubility of the substance. In addition, no chronic toxicity of SCAE Me on Eisenia fetida was observed. The obtained results indicate that Fatty acids, C12-14 (even numbered), methyl ester is likely to show no toxicity to sediment organisms as well.
Metabolisms/Bioaccumulation
Bioaccumulation in in aquatic (including sediment) organisms is not expected for Fatty acids, C12-14 (even numbered), methyl ester. After uptake by fish species, extensive and fast biotransformation of the SCAE Me(s) by carboxylesterases into fatty acids and methanol is expected. Fatty acids will be further used by these organisms as their main source of energy throughout all the different life stages (early development, growth, reproduction, etc.). Rapid metabolism of analogue ester compounds (involving hydrolysis into fatty acids and methanol) in fish has been observed in vitro, with half-lives in fish liver homogenates below 6 minutes. In vivo fish tests reported BCF values ranging from 1 to 70 for similar ester substances, supporting the argument that rapid metabolism takes place even when log Kow values are above the trigger value of 3. The supporting BCF/BAF values estimated with the BCFBAF v3.01 program also indicate that these substances will not be bioaccumulative (all well below 2000).
Conclusion
Due to its readily biodegradable nature, extensive degradation of the substance in conventional STPs will take place and only low concentrations are expected to be released (if at all) into the environment. Bioaccumulation is not expected due to low exposure and fast metabolism after oral or dermal uptake. Furthermore, aquatic toxicity data show that no effects occur up to the limit of water solubility. Therefore, Fatty acids, C12-14 (even numbered), methyl ester is unlikely to pose a risk for sediment organisms in general and testing is thus omitted.
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