Registration Dossier
Registration Dossier
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EC number: 205-391-3 | CAS number: 140-01-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48-hour EC50 for Daphnia carinata, a freshwater species, was 245 mg/L DTPA, which is equivalent to 310 mg/L pentasodium DTPA. The 96-hour LC50 for Crangon crangon, a saltwater species, was 6020 mg/L pentasodium DTPA.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 310 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 6 020 mg/L
Additional information
Four acute toxicity tests with aquatic invertebrates were assessed for this endpoint, and all four studies were found to be of good quality and reliable for use in the risk assessment process. Two studies were conducted with the freshwater cladoceran, Daphnia magna, one study was conducted with the freshwater cladoceran, Daphnia carinata,and one study was conducted with the marine brown shrimp, Crangon crangon. Both the pentapotassium and pentasodium DTPA salts as well as DTPA (free acid) were used as test substances in these exposure studies. Since the pentapotassium and pentasodium salts of DTPA dissociate when in contact with water, these salts are considered equivalent to DTPA (free acid) in aquatic environments. The 48-hour EC50 values for D. magna (after stoichiometric conversion from pentapotassium DTPA to pentasodium DTPA) ranged from > 500 to 760 mg/L pentasodium DTPA, while the EC50 value for D. carinata (after stoichiometric conversion from DTPA free acid to pentasodium DTPA) was 310 mg/L DTPA. The 96 -hour LC50 for the brown shrimp, Crangon crangon, was 6020 mg/L pentasodium DTPA. The key parameter for the freshwater studies was the EC50 value of 310 mg/L reported for D. carinata, since this is the lowest acute toxicity value reported for a freshwater invertebrate species. The key parameter for the saltwater studies was the 96-hour LC50 value of 6020 mg/L reported for the brown shrimp.
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