Registration Dossier
Registration Dossier
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EC number: 283-907-6 | CAS number: 84775-78-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Ascophyllum nodosum, Fucaceae.
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Principles of method if other than guideline:
- The partition coefficient is estimate from the solubiliy of the substance in methanol and in water:
P estimate = saturation in n-octanol/ saturation in water - GLP compliance:
- no
- Type of method:
- other: estimated by calculation
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- Pow
- Partition coefficient:
- <= 0
- Temp.:
- 22 °C
- pH:
- >= 7.4 - <= 7.5
- Type:
- log Pow
- Partition coefficient:
- <= -3.3
- Temp.:
- 22 °C
- pH:
- >= 7.4 - <= 7.5
Reference
It is not possible to define an active substance therefore a sperimental method to calcultate the partition coefficient can not be performed.
In accordance with Column 2 of REACH Annex VII, the partition coefficient (required in section 7.8) could be estimated from the solubility results, therefore:
Pow (estimate) = Coctanol / Cwater = 250.6 / 500,000 = 5.0 E -04
LogPow = Log (5.0 E-04) = -3.3
where
Coctanol: < 250.6 mg/L [from section 4.9 the solubility in methanol is 250.6 mg/L. Due the higher polarity of methanol versus n-octanol the real value is minor than 250.6 mg/L]
Cwater: >500,000 mg/L [from section 4.8]
Due the considaration above the calculate value will overestimate the real value.
Description of key information
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -3.3
- at the temperature of:
- 22 °C
Additional information
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