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EC number: 700-990-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Endpoint summary
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- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
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- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Neurotoxicity
Administrative data
Description of key information
Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure; Limit test (Protocol for acute delayed neurotoxicity studies: Section 163.81-7, U.S. Environmental Protection Agency's proposed guidelines [Federal Register 43 (163): 37362-37363, 1978]; similar to OECD 418): NOAEL (neurotoxicity): ≥ 11679 mg/kg bw/day (nominal); no neurotoxic potential.
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 11 679 mg/kg bw/day
Additional information
In the key study, the acute delayed neurotoxicity of t-BuTPP was investigated in an acute, oral, limit test (similar to OECD 418). 15 adult hens were treated with 11.7 g/kg Phosflex 51B, administered on day 1 and after three weeks. Hens were observed for six weekd. No treatment related effects were observed. It is therefore concluded that the test compound did not induce the neuropathologic alterations characteristic of delayed neurotoxicity in the hen. The NOAEL for neurotoxicity, based on adverse effects, neurobehaviour; neuropathology was ≥11679 mg/kg.
Two supporting studies, with no detailed test methods, were available for neurotoxicity. In both studies, no significant effects were observed, and it was concluded that t-BuTPP does not have neurotoxic potential.
Justification for classification or non-classification
Based on the available data, there is no evidence of neurotoxic effects for t-BuTTP. Therefore, based on the EU criteria outlined in 67/548/EEC and 1272/2008/EC t-BuTPP does not have to be classified with regard to neurotoxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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