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EC number: 204-710-3 | CAS number: 124-70-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Dichloro(methyl)(vinyl)silane
- EC Number:
- 204-710-3
- EC Name:
- Dichloro(methyl)(vinyl)silane
- Cas Number:
- 124-70-9
- Molecular formula:
- C3H6Cl2Si
- IUPAC Name:
- dichloro(methyl)vinylsilane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Sulzfeld, Germany.
- Age at study initiation: 8-11 weeks
- Fasting period before study: over night (maximum of 20 hours, until 3-4 hours after administration of the test substance)
- Housing: 3 animals per sex/cage, in labelled Macrolon cages, containing purified sawdust as bedding material.
- Diet: standard pelleted laboratory animal diet (ad libitum), from Altromin.
- Water: Tap water (ad libitum)
- Acclimation period: minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C ± 3°C
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Dehydrated olive oil with silica gel (3:1) (density:0.9139 g/ml)
- Amount of vehicle (if gavage): Dehydrated olive oil with silica gel (3:1) (density: 0.9139 g/ml)
- Justification for choice of vehicle: The vehicle was selected on request of the sponsor and based on the formulations performed at NOTOX.
MAXIMUM DOSE VOLUME APPLIED: 10ml/kg body weight
- Doses:
- 200 mg/kg and 2000 mg/kg
- No. of animals per sex per dose:
- 3M, 3F/200 mg/kg, 3F/2000mg/kg
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality and viability observations were carried out twice, daily. Body weight measurements were taken on day 1 (pre-administration), 8 and 15 and at death (if found dead after day 1).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Examinations for clinical signs were carried out at periodic intervals on the day of dosing (day 1) and once daily thereafter until day 15. The symptoms, their time of onset, degree and duration were recorded and graded according to fixed scales. - Statistics:
- No statistical analysis was performed.
Results and discussion
- Mortality:
- All animals died at the 2000 mg/kg dose level.
- Clinical signs:
- other: At the 200 mg/kg exposure level the animals showed hunched posture, piloerection, salivation and lethargy. The 2000 mg/kg dose level the animals showed lethargy, clonic spasms, hunched and flat posture, uncoordinated movements, slow breathing, piloerectio
- Gross pathology:
- Dark red discolouration of the G.I tract, forestomach, left liver and mesenteric lymph node; pale discolouration of the kidney (one or both). macroscopic post mortem examination of the surviving animals at termination did not reveal any abnormalities.
- Other findings:
- None reported.
Any other information on results incl. tables
Table 1: Number of animals dead and time range within which mortality occurred
Dose |
Mortality (# dead/total) |
Time range of deaths (hours) |
||
Male |
Female |
Combined |
||
200 |
0/3 |
0/3 |
0/6 |
- |
2000 |
- |
3/3 |
3/3 |
2 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 value within the range of 200-2000mg/kg bw was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
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