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EC number: 204-710-3
CAS number: 124-70-9
There are no repeated dose toxicity data on dichloro(methyl)(vinyl)silane or its hydrolysis product, methyl(vinyl)silanediol, so good quality data for the related substance trimethoxyvinylsilane have been used to assess the general systemic toxicity of dichloro(methyl)(vinyl)silane.In an oral OECD 422 study ( Hashima Labs, no date) in rats, trimethoxyvinylsilane was administered by gavage at doses up to 1000 mg/kg bw/day, for approximately 28 days. The LOAEL was 62.5 mg/kg bw/day (based on decreased relative thymus weight in females and histopathological changes in the urinary bladder of males) and the NOAEL was < 62.5 mg/kg bw/day for both sexes.In a 14-week whole-body inhalation study (BRRC, 1990) in which rats were exposed to trimethoxy(vinyl)silane at concentrations up to 400 ppm, a concentration of 100 ppm was a LOAEC (effects included decreased urine osmolality and sodium, potassium and chloride concentrations in males and slight decrease in body weight and body weight gain in females), and 10 ppm (58 mg/m3) was a NOAEC.
There are no repeated dose toxicity data on
dichloro(methyl)(vinyl)silane or its hydrolysis product,
methyl(vinyl)silanediol, so good quality data for the related substance
trimethoxyvinylsilane have been used to assess the general systemic
toxicity of dichloro(methyl)(vinyl)silane. Local effects from the other
hydrolysis product, hydrogen chloride (HCl) are not addressed by these
Dichloro(methyl)(vinyl)silane hydrolyses rapidly in contact with water
(half-life <1 minute at pH 7), generating HCl and
methyl(vinyl)silanediol. Trimethoxy(vinyl)silane (CAS 2768 -02 -7)
hydrolyses more slowly at pH 7 (half-life
<2.4 hours at 50°C and pH7)
For the inhalation route, the hydrolysis rate of trimethoxyvinylsilane
in the respiratory tract and lungs is unknown, but is likely to be
slower than that of dichloro(methyl)(vinyl)silane. For
dichloro(methyl)(vinyl)silane, the species absorbed following inhalation
exposure are mainly hydrolysis products, whereas for
trimethoxyvinylsilane, absorption of the parent substance may be more
significant. Trimethoxyvinylsilane has a higher log Kow value
(1.08) therefore the proportion of inhaled material which is
systemically absorbed is likely to be greater than for
dichloro(methyl)(vinyl)silane. Nevertheless, in the absence of other
data, the inhalatory NOAEL for trimethoxy(vinyl)silane is considered to
represent a reasonable worst-case for read-across to
It is of note that the oral NOAEL in rats for methanol is greater (500
mg/kg bw/day) than the dose that is expected to be generated from
hydrolysis of trimethoxy(vinyl)silane in the stomach. Therefore the
effects of trimethoxy(vinyl)silane following a dose of 62.5 mg/kg bw/day
are not thought to be attributable to methanol. Similarly, following
inhalation of methanol the NOAEC is an order of magnitide greater than
the NOAEC for trimethoxy(vinyl)silane, and it therefore unlikely that
systemic effects observed following inhalation of
trimethoxy(vinyl)silane are due to methanol.
Based on the observed effects on the urinary bladder of males at all
dose levels, it is appropriate to classify trimethoxyvinylsilane as STOT
RE 2 (bladder) following oral exposure, according to the criteria of
Regulation 1272/2008. However, at the dose levels tested, corrosive
effects of trichloro(vinyl)silane would outweigh any potential systemic
effects. It is therefore not considered appropriate to classify
trichloro(vinyl)silane for repeated dose toxicity.
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