Registration Dossier
Registration Dossier
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EC number: 204-710-3 | CAS number: 124-70-9
Endpoint summary
Administrative data
Description of key information
The key acute oral study was conducted according to OECD 423 (Acute Toxic Class method), giving an LD50 for male and female rats in the range 200 - 2000 mg/kg bw when dosed in dehydrated olive oil (NOTOX, 2003). Clinical signs observed included hunched and flat posture, piloerection, salivation, lethargy, clonic spasms, uncoordinated movements, slow breathing, and ptosis.
The key acute inhalation study was conducted according to OECD 402, giving an LC50 of approx. 2021 ppm for one-hour, whole-body exposure (DCC, 2002), (equivalent to a 4-hour LC50 of 1010 ppm (approx. 5.9 mg/l). Longer exposure times were not used due to the corrosivity of the test substance. Clinical signs and necropsy findings for animals that died during the study reflected the corrosive nature of the test substance.
No acute dermal data are available.
Key value for chemical safety assessment
Additional information
The key oral study was selected as the only available GLP, guideline-compliant study (Reliability 1).
The key inhalation study was selected as the more recent of two GLP-compliant, guideline studies (Reliability 1 and 2 respectively). The result of the supporting study is consistent with that of the key study.
The inhalation LC50is from a one hour exposure period. When this value is adjusted (divided by 2) to account for the short exposure duration, the LC50becomes 1010 ppm, which is equivalent to approximately 5.9 mg/l.
Justification for classification or non-classification
On the basis of the available measured LD(C)50 values, dichloro(methyl)(vinyl)silane is classified R20/22 'Harmful by inhalation and if swallowed', according to the criteria of EU Directive 67/548/EEC and 'Acute toxic 4 (oral)', and 'Acute toxic 3 (vapour)' under Regulation 1272/2008.
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