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Physical & Chemical properties

Vapour pressure

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Link to relevant study record(s)

Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009-10-20 to 2010-02-05
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: A GLP study conducted to current accepted guidelines.
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
In compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)).
Type of method:
effusion method: vapour pressure balance
Temp.:
25 °C
Vapour pressure:
< 0 Pa

Table 1: Tabulated Results for Run 1

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

80

353.15

2.83E-03

0.31

3.10E-10

4.30E-04

-3.37

81

354.15

2.82E-03

1.18

1.18E-09

1.64E-03

-2.79

82

355.15

2.82E-03

2.04

2.04E-09

2.83E-03

-2.55

83

356.15

2.81E-03

1.18

1.18E-09

1.64E-03

-2.79

84

357.15

2.80E-03

1.49

1.49E-09

2.07E-03

-2.68

85

358.15

2.79E-03

0.31

3.10E-10

4.30E-04

-3.37

86

359.15

2.78E-03

2.04

2.04E-09

2.83E-03

-2.55

87

360.15

2.78E-03

1.49

1.49E-09

2.07E-03

-2.68

88

361.15

2.77E-03

2.67

2.67E-09

3.71E-03

-2.43

89

362.15

2.76E-03

1.57

1.57E-09

2.18E-03

-2.66

90

363.15

2.75E-03

1.96

1.96E-09

2.72E-03

-2.57

No statistical analysis was considered necessary

Table 2: Tabulated Results for Run 2

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

80

353.15

2.83E-03

1.26

1.26E-09

1.75E-03

-2.76

81

354.15

2.82E-03

1.65

1.65E-09

2.29E-03

-2.64

82

355.15

2.82E-03

0.08

8.00E-11

1.11E-04

-3.95

83

356.15

2.81E-03

0.24

2.40E-10

3.33E-04

-3.48

84

357.15

2.80E-03

0.39

3.90E-10

5.41E-04

-3.27

85

358.15

2.79E-03

1.65

1.65E-09

2.29E-03

-2.64

86

359.15

2.78E-03

1.26

1.26E-09

1.75E-03

-2.76

87

360.15

2.78E-03

0.55

5.50E-10

7.64E-04

-3.12

88

361.15

2.77E-03

0.86

8.60E-10

1.19E-03

-2.92

89

362.15

2.76E-03

2.75

2.75E-09

3.82E-03

-2.42

90

363.15

2.75E-03

1.41

1.41E-09

1.96E-03

-2.71

No statistical analysis was considered necessary

Table 3: Tabulated Results for Run 3

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

80

353.15

2.83E-03

0.78

7.80E-10

1.08E-03

-2.97

81

354.15

2.82E-03

-0.24

-2.40E-10

n/a

n/a

82

355.15

2.82E-03

0.47

4.70E-10

6.52E-04

-3.19

83

356.15

2.81E-03

0.55

5.50E-10

7.64E-04

-3.12

84

357.15

2.80E-03

1.49

1.49E-09

2.07E-03

-2.68

85

358.15

2.79E-03

1.41

1.41E-09

1.96E-03

-2.71

86

359.15

2.78E-03

1.10

1.10E-09

1.53E-03

-2.82

87

360.15

2.78E-03

0.39

3.90E-10

5.41E-04

-3.27

88

361.15

2.77E-03

0.78

7.80E-10

1.08E-03

-2.97

89

362.15

2.76E-03

0.94

9.40E-10

1.30E-03

-2.88

90

363.15

2.75E-03

2.04

2.04E-09

2.83E-03

-2.55

No statistical analysis was considered necessary

Table 4: Tabulated Results for Run 4 

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

80

353.15

2.83E-03

2.67

2.67E-09

3.71E-03

-2.43

81

354.15

2.82E-03

7.14

7.14E-09

9.91E-03

-2.00

82

355.15

2.82E-03

1.02

1.02E-09

1.42E-03

-2.85

83

356.15

2.81E-03

0.24

2.40E-10

3.33E-04

-3.48

84

357.15

2.80E-03

4.40

4.40E-09

6.11E-03

-2.21

85

358.15

2.79E-03

0.24

2.40E-10

3.33E-04

-3.48

86

359.15

2.78E-03

2.20

2.20E-09

3.05E-03

-2.52

87

360.15

2.78E-03

1.26

1.26E-09

1.75E-03

-2.76

88

361.15

2.77E-03

0.31

3.10E-10

4.30E-04

-3.37

89

362.15

2.76E-03

0.94

9.40E-10

1.30E-03

-2.88

90

363.15

2.75E-03

1.96

1.96E-09

2.72E-03

-2.57
No statistical analysis performed Table 5: Tabulated Data for Run 5

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

80

353.15

2.83E-03

1.65

1.65E-09

2.29E-03

-2.64

81

354.15

2.82E-03

0.94

9.40E-10

1.30E-03

-2.88

82

355.15

2.82E-03

1.26

1.26E-09

1.75E-03

-2.76

83

356.15

2.81E-03

0.39

3.90E-10

5.41E-04

-3.27

84

357.15

2.80E-03

1.41

1.41E-09

1.96E-03

-2.71

85

358.15

2.79E-03

0.39

3.90E-10

5.41E-04

-3.27

86

359.15

2.78E-03

0.55

5.50E-10

7.64E-04

-3.12

87

360.15

2.78E-03

1.02

1.02E-09

1.42E-03

-2.85

88

361.15

2.77E-03

0.31

3.10E-10

4.30E-04

-3.37

89

362.15

2.76E-03

1.49

1.49E-09

2.07E-03

-2.68

90

363.15

2.75E-03

1.33

1.33E-09

1.85E-03

-2.73

No statistical analysis performed

Conclusions:
The vapour pressure of the test material was determined to be less than 3.77 x 10-4 Pa at 25°C.

Description of key information

The vapour pressure of 6-aminopenicillanic acid was determined using the EU method A4 in the study by Fox and White 2010.

Key value for chemical safety assessment

Additional information

The vapour pressure of 6 -aminopenicillanic acid was determined to be <0.000377 Pa at 25 °C