Registration Dossier
Registration Dossier
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EC number: 208-993-4 | CAS number: 551-16-6
Endpoint summary
Administrative data
Description of key information
Skin irritation:
Skin irritation potential was determined by a GLP study, comparable to current guidelines with the exception of the observation period of 3 days rather than the required 14 days.
Eye Irritation:
Eye irritation potential was investigated by a well documented GLP study which is comparable to current accepted guidelines.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin Irritation:
Based upon the observations made in the Primary Dermal Irritation Study in rabbits, 6-APA (6-Aminopenicillinic Acid), was determined not to be a dermal irritant.
Eye Irritation:
The test material was determined to be a mild irritant (class 4 in the Modified Kay and Calandra system). The maximum Group mean score was 12.7. However All effects were reversible within 72 hours.
Effects on eye irritation: slightly irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
