Registration Dossier
Registration Dossier
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EC number: 700-991-6 | CAS number: 8007-24-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
In a reverse gene mutation assay in bacteria, strains TA98, TA100, TA1535, TA 1537 and TA1538 of S. typhimurium were exposed to Cashew Nutshell Extract, Decarboxylated, Distilled (Distilled Grade), at concentrations of 0, 50, 150, 500, 1500 and 5000 µg/plate in the presence and absence of mammalian metabolic activation.
The positive controls induced the appropriate responses in the
corresponding strains. There was no evidence of induced mutant colonies
over background for the test substance.
This study is classified as acceptable. This study satisfies the
requirement for Test Guideline OECD 471 for in vitro mutagenicity
(bacterial reverse gene mutation) data.
In a mammalian cell cytogenetics assay [chromosome aberration], human
cell cultures were exposed to Cashew Nutshell Extract, Decarboxylated,
Distilled (Distilled Grade) at concentrations of 0, 1.56, 3.125, 6.25,
25 and 50 µg/ml without S9 metabolic activation and 0, 0.78, 1.56,
3.125, 6.25, 12.5 and 25 with S9 metabolic activation.
Positive controls induced the appropriate response. There was no
evidence of chromosome aberrations induced over background with the test
substance.
This study is classified as acceptable. This study satisfies the
requirement for Test Guideline OECD 473 for in vitro cytogenetic
mutagenicity data.
In a mammalian cell gene mutation assay [HGPRT], Chinese hamster ovary
cell cultures were exposed to cashew nutshell liquid at concentrations
of 0, 0.75, 1.5, 3, 6 and 12 µg/ml without S9 metabolic activation and
0, 1.5, 3, 6, 12 and 18 with S9 metabolic activation.
Positive controls induced the appropriate response. There was no
evidence of mutations induced over background with the test substance.
This study is classified as acceptable. This study satisfies the
requirement for Test Guideline OECD 476 for in vitro mammalian gene cell
mutagenicity data.
Endpoint Conclusion:No adverse effect observed (negative)
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Negative results have been obtained in in vitro gene mutation, mammalian cell cytogenetic assay (chromosome aberration) and a mammalian cell gene mutation assay, therefore, Cashew Nutshell Extract, Decarboxylated, Distilled (Distilled Grade) is not considered to be genotoxic in vitro.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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