Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 204-435-9 | CAS number: 120-92-3
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The purity of the test substance was not reported. The protocols were quite described but the results were not detailed enough and the determination of the activities was confused. The GLP were not mentioned.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- An evaluation of the utility of four in vitro short term tests for predicting the cytotoxicity of individual compounds derived from tobacco smoke.
- Author:
- Curvall M., Enzell C.R. and Pettersson B.
- Year:
- 1 984
- Bibliographic source:
- Journal Cell Biology and Toxicology, Vol. 1, p.173-193.
- Reference Type:
- publication
- Title:
- Effects of tobacco smoke compounds on the noradrenaline induced oxidative metabolism in isolated brown fat cells.
- Author:
- Pettersson B., Curvall M., Enzell C.R. (1980) .
- Year:
- 1 980
- Bibliographic source:
- Journal Toxicology, Vol. 18, p.1-15
- Reference Type:
- publication
- Title:
- Effects of tobacco and tobacco smoke constituents on cell multiplication in vitro.
- Author:
- Pilotti A., Ancker K., Arrhenius E., Enzell C.
- Year:
- 1 975
- Bibliographic source:
- Journal Toxicology, Vol. 5, p.49-62.
- Reference Type:
- publication
- Title:
- Effect of tobacco smoke compounds on the plasma membrane of cultured human lung fibroblasts.
- Author:
- Thelestam M., Curvall M., Enzell C.R.
- Year:
- 1 980
- Bibliographic source:
- Journal Toxicology, Vol. 15, p.203-217.
Materials and methods
- Type of study / information:
- Cytotoxicity: evaluation of the short-term tests for predicting the cytotoxicity
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclopentanone
- EC Number:
- 204-435-9
- EC Name:
- Cyclopentanone
- Cas Number:
- 120-92-3
- Molecular formula:
- C5H8O
- IUPAC Name:
- cyclopentanone
- Details on test material:
- The origin of cyclopentanone and cyclohexanone were not reported but their purity was checked by thin-layer chromatography, gas chromatography or NMR. If the test substance contained more than 3% impurity, it was purified using liquid chromatography, recrystallization and distillation.
Constituent 1
Results and discussion
Any other information on results incl. tables
Based on its toxicity in all four systems (A(cg)=0, A(om)=0, A(ca) and A(md)=0) cyclopentanone showed a low mean activity, A(t) = 0.
Based on its toxicity in all four systems (A(cg)=0, A(om)=1, A(ca) and A(md)=0) cyclohexanone showed a low mean activity, A(t) = 0.3.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
