Registration Dossier
Registration Dossier
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EC number: 429-270-1 | CAS number: 136210-30-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
A study to investigate the potential of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester to accumulate in fish yielded an uptake efficiency of 0.25 % . After a short depuration phase, even very low levels of the accumulated test item are quickly eliminated. The study clearly shows that the test item has no significant potential for bioaccumulation and is thus neither a PBT nor a vPvB substance. Furthermore, no hints on potential metabolites of the test item became visible during the study.
Key value for chemical safety assessment
Additional information
The test was conducted using spiked fish food instead of water as exposure route. Dietary bioaccumulation tests are practically much easier to conduct for poorly water-soluble substances, because a higher and more constant exposure to the substance can be administered via the diet than via water especially in cases where substances are sensitive towards hydrolysis.
Study was performed with aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester which is a structural analogue to aspartic acid, N,N'-(methylenedi-4,1-cyclohexanediyl)bis-, 1,1',4,4'-tetraethyl ester.Both substances are diethyl esters of aspartic acid linked to a dicyclohexylmethyldiamine moiety. The difference between these two substances is merely the presence of two methyl groups connected to the cyclohexane rings. This structural analogy was confirmed by the Member State responsible for the notification of both substances under the NONS regulation. The Member State decided that test results obtained for one substance can be transferred to the other substance and that testing of both substances is usually not required. This decision is in accordance with the grouping of substances and read-across approach in Annex XI, 1.5 of the REACH Regulation.
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