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Environmental fate & pathways

Hydrolysis

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Description of key information

The stability of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester towards hydrolysis was determined according to the OECD-guideline 111 (Bayer Industry Services, 2006). Based on kinetic parameters, the following dissipation half-lives for a temperature of 25 °C were extrapolated based on the Arrhenius equation:
pH 4 (25 °C): t1/2: 655 h
pH 7 (25 °C): t1/2: 25.4 h
pH 9 (25 °C): t 1/2: 16.8 h
Bis-aspartic-mono-acid triethylester, bis-aspartic-di-acid diethylester, bis-aspartic-tri-acid monoethylester and bis-aspartic-tetra-acid of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester could be determined as hydrolysis products by the means of a HPLC-MS method.

Key value for chemical safety assessment

Half-life for hydrolysis:
25.4 h
at the temperature of:
25 °C

Additional information

According to the OECD-guideline 111, the stability of the test substance was experimentally determined at three different pH values (pH 4, 7 and 9) for two temperatures (35 °C and 50 °C), but prevailing temperatures in the environment and during ecotoxicological as well as toxicological assays will normally be lower. Thus, to adequately assess the behaviour of the test substance under these circumstances, the dissipation half-life was extrapolated for a temperature of 25 °C. Based on these results it can be stated that aspartic acid, N,N'[methylenebis(2 -methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'- tetraethyl ester is stable under acidic conditions, whereas the dissipation half-life decreases with increasing pH-values.

Study was performed with aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester which is a structural analogue to aspartic acid, N,N'-(methylenedi-4,1-cyclohexanediyl)bis-, 1,1',4,4'-tetraethyl ester. Both substances are diethyl esters of aspartic acid linked to a dicyclohexylmethyldiamine moiety. The difference between these two substances is merely the presence of two methyl groups connected to the cyclohexane rings. This structural analogy was confirmed by the Member State responsible for the notification of both substances under the NONS regulation. The Member State decided that test results obtained for one substance can be transferred to the other substance and that testing of both substances is usually not required. This decision is in accordance with the grouping of substances and read-across approach in Annex XI, 1.5 of the REACH Regulation.

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