Registration Dossier
Registration Dossier
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EC number: 221-435-4 | CAS number: 3091-25-6
Endpoint summary
Administrative data
Description of key information
Acute toxicity: oral, 004: Rat LD50 = 3800 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 080 mg/kg bw
Additional information
The key study was selected on the basis than it was the only one performed in accordance with an OECD test guideline. The LD50 of 3080 mg/kg bw shows that trichlorooctylstannane has low acute toxicity to rats via the oral route. All of the supporting studies had LD50 values in excess of 2000 mg/kg and therefore supported the view that trichlorooctylstanne demonstrated low acute oral toxicity.
Acute toxicity: oral, 001: Male/female LD50 = 2400 (95% confidence limits: 2200-2600) mg/kg bw.
Acute toxicity: oral, 002: Male/female LD50 = 3080 (95% confidence limits: 2176-5404) mg/kg bw.
Acute toxicity: oral, 003: Male rat LD50 = 4600 mg/kg bw.
Acute toxicity: oral, 005: Rat LD50 = Rat LD50 = 2394-3705 mg/kg bw . The LD50 in mice is given as 4600 mg/kg bw.
Justification for classification or non-classification
The acute oral male/female LD50 3800 mg/kg bw is greater than the threshold value of 2000 mg/kg bw as defined by the European DSD and CLP. Therefore, no classification with respect to acute oral toxicity is required.
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