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Description of key information

The key study for acute oral toxicity reports an LD50 value of >2000mg/kg with unremarkable findings at necropsy (Sasol, 1998; rel 1). Similarly, an LD50 of >2000mg/kg is reported for acute dermal toxicity (Sasol, 1998; rel 1). The data for acute inhalation toxicity is waived based on the low toxicity of related alcohols via the inhalation route across category, and the availability of high reliability studies via the oral and dermal routes.

Key value for chemical safety assessment

Additional information

The most recent and high reliability information were assigned as key studies. The data for acute inhalation toxicity was waived based on the premise that high reliability data was available via the oral and dermal routes, in accordance with current REACH requirements, Section 8.5.2 in Annex VIII. Furthermore, based on the information on other alcohols across category, the LC50 for inhalation toxicity is expected to be greater than the substantially saturated vapour concentration.

The most recent and high reliability sources where selected as key information. The available supporting studies for acute oral and dermal toxicity were all of high reliability and in agreement with the key information.

The presence of branched structures does not appear confer it any different toxicological properties compared to the Alcohols, C12 -13 linears only substance. Therefore the data is freely read-across between Alcohols, C12 -13 -branched and linear and Alcohols, C12 -13 substances.

In some cases the CAS and chemical identity stated refer to SDA nomenclature for this substance. In REACH substance identification it is necessary to be more specific as to the chain lengths present. Full details may be found in the CSR.

Justification for classification or non-classification

Acute toxicity tests of Alcohols, C12 -13 -branched and linear do not indicate any potential hazard for acute, dermal or inhalation toxicity. Tests on similar substances included in this category are also supportive of these results; which do not warrant classification for any acute toxicity endpoint under DSD or GHS criteria. The substance is therefore not classified for acute toxicity in accordance with EC regulation 1272/2008.

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