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EC number: 629-693-3 | CAS number: 740817-83-8
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- Toxicological Summary
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- Irritation / corrosion
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- Genetic toxicity
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- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD guideline and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Method: other: An amount of 0.1 ml of test material was instilled in the conjunctival sac of the right eye. The upper and lower lids were then held together for 1 second. The left eye was untreated and served as the control.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alcohols, C10-16
- EC Number:
- 267-019-6
- EC Name:
- Alcohols, C10-16
- Cas Number:
- 67762-41-8
- IUPAC Name:
- tetradecan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Safol(TM) 23 Alcohol C10-16 alcohols Type B (also known as Compound 33A). Equivalent to Alcohols, C12-13-branched and linear (CAS 740817-83-8).
- Physical state: clear transparent liquid
- Storage condition of test material: at ambient temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Broekman Institute, Someren, The Netherlands
- Age at study initiation: young adults
- Weight at study initiation:1870-2132g
- Housing: individually housed in stainless stel cages with perforated floor
- Diet: standard laboratory rabbit diet, ad libitum
- Water: tap water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/-3
- Humidity (%): 40-82.5
- Air changes (per hr): ca. 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- single instillation, not washed
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3M
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not rinsed
SCORING SYSTEM: According to guideline
TOOL USED TO ASSESS SCORE: not reported
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24/48/72h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- All scores at 24/48/72 hours were 0 in all animals.
At 1 hour after treatment, slight redness of the conjunctivae (grade 1 vessels definitely injected) was observed in all animals. At 24, 48, and 72 hours, no signs of eye irritation were observed in any of the 3 animals. Fully reversible in the 72 hour observation period. - Other effects:
- None reported.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Safol(TM) 23 Alcohol C10-16 alcohols Type B (also known as Compound 33A) is not an eye irritant according to EU or GHS criteria.
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