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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
No guideline is specified; a relatively brief report is given. The neat material was applied to the intact belly skin of rabbits for 15 or 30 seconds, 1 or 2 minutes.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dichloro(methyl)(phenyl)silane
EC Number:
205-746-2
EC Name:
Dichloro(methyl)(phenyl)silane
Cas Number:
149-74-6
Molecular formula:
C7H8Cl2Si
IUPAC Name:
dichloro(methyl)(phenyl)silane

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
15 sec
30 sec
1 min
2 min
Observation period:
not stated
Number of animals:
not stated - possibly one

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: slight erythema and necrosis
Time point:
other: 15 seconds
Irritation parameter:
other: marked necrosis
Time point:
other: 1 minute

Any other information on results incl. tables

15 seconds slight erythema and necrosis

30 seconds slight erythema and necrosis

1 minute marked necrosis

2 minutes marked necrosis

Applicant's summary and conclusion

Conclusions:
A limited report of a study without guideline or GLP compliance recorded slight necrosis and marked necrosis to rabbit skin, following contact for 15 seconds and 1 minute, respectively, with the neat material.