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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
No guideline is specified; a relatively brief report is given. The neat material was applied to the intact belly skin of rabbits for 15 or 30 seconds, 1 or 2 minutes.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dichloro(methyl)(phenyl)silane
EC Number:
205-746-2
EC Name:
Dichloro(methyl)(phenyl)silane
Cas Number:
149-74-6
Molecular formula:
C7H8Cl2Si
IUPAC Name:
dichloro(methyl)(phenyl)silane

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
15 sec
30 sec
1 min
2 min
Observation period:
not stated
Number of animals:
not stated - possibly one

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: slight erythema and necrosis
Time point:
other: 15 seconds
Irritation parameter:
other: marked necrosis
Time point:
other: 1 minute

Any other information on results incl. tables

15 seconds slight erythema and necrosis

30 seconds slight erythema and necrosis

1 minute marked necrosis

2 minutes marked necrosis

Applicant's summary and conclusion

Conclusions:
A limited report of a study without guideline or GLP compliance recorded slight necrosis and marked necrosis to rabbit skin, following contact for 15 seconds and 1 minute, respectively, with the neat material.