Reaction mass of 1H-Benzotriazole-1-methanamine, N,N-bis(2-ethylhexyl)-6-methyl- and 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-5-methyl- and N,N-bis(2-ethylhexyl)-4-methyl-1H-benzotriazole-1-methylamine and 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-4-methyl- and N,N-bis(2-ethylhexyl)-5-methyl-1H-benzotriazole-1-methylamine

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

only DRAFT report available, the final report is expected later.

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: not applicable

Principles of method if other than guideline:

Investigations on the partition coefficient n-octanol/water (Pow) (OECD Guideline 117, HPLC meth-od) were carried out (see additional information). With knowledge of the instability of the test item when applying chromatographic conditions (see GLP-study 20L00222 (water solubility from Com-petence Center Analytics, BASF SE, D-67056 Ludwigshafen)), it must be stated that the log Pow cannot be determined. The peaks detected using the HPLC method could be attributed to the test item

GLP compliance:

no

Type of method:

other: not applicable

Partition coefficient type:

octanol-water

Key result

Type:

log Pow

Remarks on result:

not determinable because of methodological limitations

The partition coefficient n-octanol/water (Pow) of the test item cannot be determined, due to the instability of the test item under the prescribed chromatographic conditions. This was shown during pre-tests for the determination of the log Pow by HPLC (OECD Guideline 117) (see additional information)

The determination of the log Pow according to the OECD Guideline 107 (shake flask method) is not feasible because no suitable analytical method was found for the determination of the test item in water.

Moreover, the partitioning is influenced by the instability of the test item in water (see GLP-study no. 20L00223 (hydrolysis study from Competence Center Analytics, BASF SE, D-67056 Ludwigshafen.))

Under such trying circumstances the log Pow may be stated as an estimate from the single solubilities of the test item in water and in n-octanol, which is also not possible due to the lack of sensi-tive determination methods for the test item in water. The solubili-ty of the test item in water can only be determined as “less than”. Whereas the test item is completely miscible with n-octanol.

 

Conclusions:

The log Pow could not be determined because no suitable analytical method was found for the determination of the test item in water.
The test item is completely miscible with n-octanol.

Description of key information

The log Pow could not be determined because no suitable analytical method was found for the determination of the test item in water.

Additional information

Overall, the determination was complicated further by the hydrolytic instability of the test item and the low water solubility.
For further details of the instability of the test item and the behaviour in water see GLP-study 20L00222 (water solubility) and 20L00223 (hydrolysis as a function of the pH), from Competence Center Analytics, BASF SE, D-67056 Ludwigshafen.

The test item is completely miscible with n-octanol.