Registration Dossier
Registration Dossier
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EC number: 232-234-6 | CAS number: 7790-94-5
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Toxicological Evaluations 14
- Author:
- BG Chemie
- Bibliographic source:
- Potential Health Hazards of Existing Chemicals
- Reference Type:
- publication
- Title:
- Toxicology of the eye.
- Author:
- Grant WM
- Year:
- 1 974
- Bibliographic source:
- 2nd ed., pp-279-280. Charles C. Thomas Publisher, Springfield, Illinois.
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- eye irritation
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- Chlorosulphuric acid
- EC Number:
- 232-234-6
- EC Name:
- Chlorosulphuric acid
- Cas Number:
- 7790-94-5
- Molecular formula:
- ClHO3S
- IUPAC Name:
- sulfurochloridic acid
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 1
- Sex: male - Ethical approval:
- not specified
- Route of exposure:
- dermal
- ocular
- Reason of exposure:
- accidental
- Exposure assessment:
- not specified
- Details on exposure:
- A laboratory technician accidentally dropped a 30 mL flask of chlorosulphuric acid (which also contained chlorobenzene) into water, causing an explosion, which sprayed the reaction mixture into his face.
Results and discussion
- Clinical signs:
- The technician suffered blurred vision and breathing difficulties immediately, but he was still able to rinse his eyes with water within few seconds. The burns to the cornea and conjunctiva were limited to the opening between the eyelids. His eyelids were more severely burned, and subsequently underwent increasing swelling with the loss of patches of skin.
- Effectivity of medical treatment:
- However, healing began within two weeks, and the corneas showed only small areas of unhealed epithelium with slight oedema and occasional stromal vessels near the lower limbus. His vision returned to normal.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
