Registration Dossier
Registration Dossier
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EC number: 243-072-0 | CAS number: 19438-60-9
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
Partition coefficient (LogPow): 2.09 as methyl-4-hexahydrophthalic anhydride
Partition coefficient (LogD): 1.4 as 1,2-Cyclohexanedicarboxylic acid, 4-methyl- (undissociated)
Partition coefficient (LogD): -3.95 as 1,2-Cyclohexanedicarboxylic acid, 4-methyl- (dissociated, environmental conditions)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -3.95
- at the temperature of:
- 20 °C
Additional information
Partition coefficients have been investigated using methods in accordance with accepted OECD/EU test and in-silico methods.
A LogPow of 2.09 was determined for methyl-4-hexahydrophthalic anhydride (4-MHHPA)
4-MHHPA is hydrolysed practically instantaneously to 1,2-Cyclohexanedicarboxylic acid, 4-methyl (4-MHHPAc), then for the environmental and PBT assessments, the acid form was considered more significant, with logD= -3.96 at pH= 8 (water, environmental conditions).
Considering all the charge-state forms of 4-MHHPAc dissolved in water and in octanol, a LogD (distribution coefficient) was estimated taking account for the pH dependence of the substance in aqueous solution.
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