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EC number: 939-591-3 | CAS number: 1471315-74-8
- Life Cycle description
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxicity observed even at highest concentration level tested.
Oncorhynchus mykiss, OECD 203, limit static test: LL50(96h) > 1000 mg/L WAF, NOEL(96h): 1000 mg/L WAF
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
Shacklady (2011) investigated the acute toxicity of the test substance towards fish according to OECD Guideline 203. Rainbow trout (Oncorhynchus mykiss) was used as test organisms, since it is a freshwater representative of a wide variety of natural habitats and is considered as an important non-target organism in freshwater ecosystems. Based on the inherent substance properties (complex mixture, poor water solubility), Water Accomodated Fractions (WAFs) were prepared. This approach is endorsed by several regulatory authorities in the EU and furthermore i.e. ECETOC and OECD. Aqueous media are prepared by mixing the test substance with water for a prolonged time (24 - 48 h) to ensure equilibration between the substance and water phase. Separation is done with the help of a siphon and the test animals are exposed to the WAFs. Based on the outcome of the range finding study (no mortality and no sub-lethal effects up to 1000 mg/L), the definitive test was conducted as limit test with a single concentration of 1000 mg/L in two replicates. A static test regime was applied and a control group was included. 10 fish were placed in each vessel in random, giving a loading rate of 0.49 g bw/L. Physico-chemical (temperature, pH and dissolved oxygen) and stirring rate measurements were performed daily and no abnormalities were recorded. The total exposure period was 96 hours with a photoperiod of 16/8 (light/dark) with 20 min dawn and dusk transition periods. The animals received no food, the vessels were aerated via narrow bore glass tube. After the exposure period, no mortality and no sub-lethal effects were observed, thus the No Observed Effect Loading rate (NOEL) is 1000 mg/L. The LL50 (Lethal Loading rate) is > 1000 mg/L. It was considered unneccessary and unrealistic to test at loading rates in excess of this concentration. The toxicity data demonstrate that the substance is not toxic to fish even at the highest test substance concentrations tested.
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