Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 939-591-3 | CAS number: 1471315-74-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An extended assessment of the toxicokinetic behaviour of the UVCB substance was performed, taking into account the chemical structure, the available physico-chemical-data and the available toxicity data.
Data source
Referenceopen allclose all
- Reference Type:
- other: Expert Statement
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
- Reference Type:
- other: Prediction by the OECD QSAR Toolbox
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: TGD, Part I, Annex IV, 2003); ECHA guidance R7c., 2008
- Deviations:
- no
- Principles of method if other than guideline:
- An assessment of toxicological behaviour of the UVCB target substance is based on its physico-chemical properties and on the results of available toxicity data data.
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction Products of alcohols, C14-18, C18 unsat., esterified with phosphorus pentoxide and salted with amines, C12-14,-tert-alkyl
- EC Number:
- 939-591-3
- Cas Number:
- 1471315-74-8
- Molecular formula:
- Not available
- IUPAC Name:
- Reaction Products of alcohols, C14-18, C18 unsat., esterified with phosphorus pentoxide and salted with amines, C12-14,-tert-alkyl
- Test material form:
- other: liquid
Constituent 1
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Low absorption potential via all exposure routes is due to the large molecule size (MW of > 533.82 < 784.29 g/mol), high lipophilicity (LogPow of 8.0) and low water solubility (1.64 mg/L).
- Type:
- distribution
- Results:
- Entering the body, no wide distribution is expected due to the large molecule size.
- Type:
- metabolism
- Results:
- If absorbed, hydroxylation of C atoms of the carbon chains is the primary reaction expected (Phase I) with subsequent conjugation reactions (Phase II).
- Type:
- excretion
- Results:
- Conjugated metabolites are expected to be excreted via the urine or via the faeces.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Derivatives of hydroxilation, oxidation reactions and hydrolysis (only in GI tract).
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
Low bioaccumulation potential is predicted for the target UVCB substance based on the high lipophilicity (LogPow of 8.0). - Executive summary:
An assessment of toxicokinetic behaviour of the UVCB target substance was performed, taking into account the chemical structure, the available physico-chemical-data and the available toxicity data. The substance is not expected to be absorbed from GI tract by passive diffusion. A high systemic availability via dermal and inhalation routes is unlikely. If absorbed, it is expected to be predominantly distributed into fatty tissues due to its MW of > 533.82 < 784.29 and low water solubility (1.64 mg/L). The substance can enter the cell inner (LogPow of 8.0) only to alimited extent. Low risk for accumulation is expected for the UVCB target substance (LogPow is >4.0). Possible reactions: hydroxylation, oxidation and hydrolysis (only dialkyl phosphate ester) by Phase I enzymes with subsequent conjugation reactions. Conjugates are expected to be excreted via the urine or via the faeces. Parent compound is expected to be excreted via the faeces.
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