Registration Dossier
Registration Dossier
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EC number: 435-740-7 | CAS number: 94317-64-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- EPA OPPTS 870.3100 (90-Day Oral Toxicity in Rodents)
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- other: Crl:CD BR
- Sex:
- male/female
- Route of administration:
- other: oral: diet
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- daily in diet
- Remarks:
- Doses / Concentrations:
0;200;1000;5000 ppm
Basis:
nominal in diet - No. of animals per sex per dose:
- 15
- Dose descriptor:
- NOAEL
- Effect level:
- 74 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: 90 days
- Dose descriptor:
- LOAEL
- Effect level:
- 17 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: 90 days
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 17 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- In a 90d study according to US EPA for males the NOAEL was 74 mg/kg/d, for females the LOAEL 17 mg/kg/d
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
