Registration Dossier
Registration Dossier
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EC number: 435-740-7 | CAS number: 94317-64-3
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- No information
- Author:
- Anonymous
- Year:
- 2 011
- Bibliographic source:
- NICNAS (Australia)
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 416 (Two-Generation Reproduction Toxicity Study)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- -
- EC Number:
- 435-740-7
- EC Name:
- -
- Cas Number:
- 94317-64-3
- Molecular formula:
- C4H14N3PS
- IUPAC Name:
- Phosphorothioic triamide, N-butyl-
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- daily in diet
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0;200;800;3200 ppm
Basis:
nominal in diet
- No. of animals per sex per dose:
- 8
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 21 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: From two-generation reproductive tox study
- Dose descriptor:
- NOAEL
- Effect level:
- 17 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: From 90d repeated dose study
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- > 3 200 ppm (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: From two-generation reproductive tox study
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
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