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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
No information
Author:
Anonymous
Year:
2011
Bibliographic source:
NICNAS (Australia)

Materials and methods

Test guideline
Guideline:
other: OECD
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
435-740-7
EC Name:
-
Cas Number:
94317-64-3
Molecular formula:
C4H14N3PS
IUPAC Name:
Phosphorothioic triamide, N-butyl-

Method

Species / strain
Species / strain / cell type:
S. typhimurium, other: TA98, TA100, TA1535, TA1537
Metabolic activation:
with and without
Metabolic activation system:
no data
Test concentrations with justification for top dose:
between 333 and 500 microgram per plte, resp. 0.1 to 5.0 milligram/l

Results and discussion

Test results
Species / strain:
S. typhimurium, other: TA98, TA100, TA1535, TA1537
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not determined
Additional information on results:
All results were negative

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

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