Registration Dossier
Registration Dossier
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EC number: 610-199-1 | CAS number: 446292-04-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No antigen specific activation of the cells of the immune system via dermal route was determined after application of up to and including 50% 4 -84 -Nitrophenyl)-3 -morpholinon. No indication for a non-specific (irritating) activation was detected, too. A slight statistically significant increase compared to vehicle treated animals regarding ear weight was detected in the low dose group. However, this change was within the normal variance of this parameter, and thus to be judged of no biological relevance.
Therefore, the study does neither point to a non-specific (irritating) nor to a specific immunostimulating (sensitising) potential of the test item.
Migrated from Short description of key information:
Skin Sensitisation, LLNA/IMDS (NMRI mice, GLP, OECD TG 429, 406 and EPA OPPTS 870.2600): no non-specific (irritating) or specific immunostimulating (sensitising) properties
[Bayer AG, Report No. PH-34724, 2007-01-11]
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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