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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study with limited documentation and with no data on GLP compliance. In the OECD SIDS on 2-Naphthol (2002) a similar reliability was assigned.

Data source

Reference
Reference Type:
publication
Title:
Comparative aquatic toxicology of aromatic hydrocarbons
Author:
Black et al.
Year:
1983
Bibliographic source:
Black JA et al; Fundam Appl Toxicol 3 (5): 353-8 (1983)

Materials and methods

Test guideline
Guideline:
other: embryo-larval test
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-naphthol
EC Number:
205-182-7
EC Name:
2-naphthol
Cas Number:
135-19-3
Molecular formula:
C10H8O
IUPAC Name:
2-naphthol

Sampling and analysis

Analytical monitoring:
yes

Test organisms

Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)

Study design

Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
27 d
Post exposure observation period:
Exposure was initiated 20 min after fertilization, average hatching times were 23 d, and was continued through 4 days posthatching.

Test conditions

Hardness:
water hardness: 86.8-116.3 mg/l CaCO3
Test temperature:
13.3 - 14.2 degree C
pH:
7.4 - 8.1
Dissolved oxygen:
8.6-10.2 mg/l
Salinity:
no data
Nominal and measured concentrations:
no data
Details on test conditions:
Flow-rate 200 ml/h
Retention time 2.5 h
100-150 eggs/exposure chamber
Daily analysis of test concentration; 4 - 6 test concentrations, 2 replicates/test

Results and discussion

Effect concentrationsopen allclose all
Duration:
23 d
Dose descriptor:
LC50
Effect conc.:
0.08 mg/L
Basis for effect:
other: embryo larval mortality and teratogenesis
Remarks on result:
other: 95 % Conf. Lim. 0.06 - 0.1 mg/l
Duration:
27 d
Dose descriptor:
LC50
Effect conc.:
0.07 mg/L
Basis for effect:
other: embryo larval mortality and teratogenesis
Remarks on result:
other: 95 % Conf. Lim. 0.06 - 0.09 mg/l
Duration:
27 d
Dose descriptor:
NOEC
Effect conc.:
0.001 mg/L
Basis for effect:
other: embryo larval mortality and teratogenesis
Details on results:
Teratic larvae were observed at frequencies of 2 % to 36 % over an exposure range of 0.001 to 0.907 mg/l. The LC50 value was 0.08 mg/l (95 % Conf. Lim. 0.06 - 0.1 mg/l) at hatching and 0.07 mg/l (95 % Conf. Lim. 0.06 - 0.09 mg/l) at 4 days posthatching.

Applicant's summary and conclusion

Conclusions:
Using embryo larval stages of the rainbow trout, continuous flow toxicity tests were performed on beta-naphthol. LC50 based on combined frequencies of embryo larval mortality and teratogenesis were 0.08 mg/l at hatching (23d) and 0.07 mg/l at 4 days posthatching.