Registration Dossier
Registration Dossier
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EC number: 639-864-4 | CAS number: 43133-95-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
In a study of the metabolism of commercial hexane, n-hexane was metabolized and excreted within 168 h of iv bolus administration, inhalation exposure or dermal application. Exhaled breath and urine were the two primary routes for the excretion and its metabolites. n-Hexane was widely distributed to the body tissues but neither n-hexane nore its metabolites were concentrated significantly by any of those tissues. It was extensively metabolized and a number of radio labeled metabolites were excreted in the urine. n-Hexane and its radio labeled metabolites disappeared from the blood of rats with a half-life of approximately 9-10 hours. No significant differences between males and females were noted in the rates and routes of metabolism and excretion of the test compounds. Repeated inhalation exposure had no apparent effect on the rates or routes of excretion of either of the test compounds or their metabolites.
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