Registration Dossier
Registration Dossier
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EC number: 639-864-4 | CAS number: 43133-95-5
Endpoint summary
Administrative data
Description of key information
One key read across study for skin irritation was identified (Shell, 1987; Klimisch score=2). One key read-across eye irritation study of C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexane was identified (Hine, 1970; Klimisch score=2).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In a key read across skin irritation study (Shell, 1987; Klimisch score=2), the skin irritancy of the test substance a hexane solvent containing <5% n-hexane was examined. Groups of six rabbits had 0.5 ml of test substance applied to their dorsal skin. The test area was covered semi-occlusively, and exposure lasted 4 hours. The test area was then washed. Animals were evaluated for erythema and oedema at 30 min., 24 hrs, 48 hrs, 72 hrs, and 7 days after removal of the test substance. The average erythema score (24,48, and 72 hours) was 0.8. The average oedema score (24,48, and 72 hours) was 0.0.
In a key read-across eye irritation study of C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexane (Hine, 1970; Klimisch score=2), 0.1 mL of test substance was placed in the eyes of six male rabbits. The rabbits were examined for signs of irritation at 24, 48, and 72 hrs after start of exposure. Only 1 animal showed signs of irritation (score of 1) at 24 hrs. The mean conjunctivae, chemosis, iris, and cornea scores were 0.33, 0.0, 0.0, and 0.0 respectively.
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
Based on the read across studies described in the dossier, the substance is not classified as a skin or eye irritant. However, since methypentane constituents have harmonized classification pursuant to Annex VI of CLP Regulation as Skin Irrit. 2 H315Causes skin irritation, then the substance is classified accordin to this legal statement.
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