Registration Dossier
Registration Dossier
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EC number: 222-619-7 | CAS number: 3558-60-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data for the target chemical is summarized based on the structually and functionally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: refer below principle
- Principles of method if other than guideline:
- WoE study was prepared for toxicity of test chemical by considering WoE 2 and 3
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Test organisms (species):
- other: 2: Pseudomonas putida; 3:Tetrahymena pyriformis
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 17 h
- Remarks on exposure duration:
- 3: 48 h
- Duration:
- 17 h
- Dose descriptor:
- EC10
- Effect conc.:
- 840 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: 2
- Duration:
- 17 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: 2
- Duration:
- 17 h
- Dose descriptor:
- other: EC90
- Effect conc.:
- 2 300 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: 2
- Duration:
- 48 h
- Dose descriptor:
- IC50
- Effect conc.:
- 853.47 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: 686.42 - 1057.02 mg/L
- Remarks:
- 3
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Study was carried out to determine the toxic effect of test chemical on Pseudomonas putida . Based on the effect of test chemical on growth of the test organism, the 17 h EC10, EC50 and EC90 value was determined to be 840, 1320 and 2300 mg/l respectively and 48 h IC50 determined to be 853.47 mg/L.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of the test chemical to micro-organism .The studies are as mentioned below:
Toxicity to micro-organism study was carried out for 17 h to determine the effect of test chemical on micro-organism. Pseudomonas putida was used as test organism. Based on the effect of test chemical on growth of the test organism, the EC10, EC50 and EC90 value was determined to be 840, 1320 and 2300 mg/l respectively.
Toxicity to micro-organism study was carried out for 48 h to determine the effect of test chemical on micro-organism. Tetrahymena pyriformis was used as test organism. Based on the effect of test chemical on growth rate of the test organism, the IC50 value was determined to be 853.47 mg/L.
Reference
Description of key information
Study was carried out to determine the toxic effect of test chemical on Pseudomonas putida . Based on the effect of test chemical on growth of the test organism, the 17 h EC10, EC50 and EC90 value was determined to be 840, 1320 and 2300 mg/l respectively and 48 h IC50 determined to be 853.47 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 320 mg/L
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of the test chemical to micro-organism .The studies are as mentioned below:
Toxicity to micro-organism study was carried out for 17 h to determine the effect of test chemical on micro-organism. Pseudomonas putida was used as test organism. Based on the effect of test chemical on growth of the test organism, the EC10, EC50 and EC90 value was determined to be 840, 1320 and 2300 mg/l respectively.
Toxicity to micro-organism study was carried out for 48 h to determine the effect of test chemical on micro-organism. Tetrahymena pyriformis was used as test organism. Based on the effect of test chemical on growth rate of the test organism, the IC50 value was determined to be 853.47 mg/L.
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