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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from handbooks and peer reviewed journals

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
DPIM: PFD325
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials):Food and Chemical Toxicology. 20(Suppl) (1982), 807.
Reference Type:
other: Secondary Literature
Title:
RTECS: KO2230000
Author:
RTECS
Year:
1997
Bibliographic source:
RTECS, 1997
Reference Type:
publication
Title:
Monographs of Fragrance Raw Materials – Phenethyl methyl ether
Author:
D.L.J Opdyke
Year:
1982
Bibliographic source:
Food and Chemical Toxicology, 1982

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of the test chemical in rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material: Benzene(-2-methoxyethyl)
- Molecular formula: C9H12O
- Molecular weight: 136.193 g/mole
- Smiles : COCCc1ccccc1
- Inchl: InChI=1/C9H12O/c1-10-8-7-9-5-3-2-4-6-9/h2-6H,7-8H2,1H3
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact and abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
24 hours
Observation period:
24 hours
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Mild irritation was observed

Applicant's summary and conclusion

Interpretation of results:
other: Mild irritant
Conclusions:
Undiluted test chemical was mildly irritating to the intact and abraded skin of rabbits after 24 hours exposure. Hence, the test chemical can be considered to be irritating to skin.
Executive summary:

A skin irritation study was performed in rabbits to assess the irritation potential of the test chemical. Undiluted test chemical was applied to the intact and abraded skin of rabbits for 24 hours under occlusion and observed for effects.

 

Undiluted test chemical was mildly irritating to the intact and abraded skin of rabbits after 24 hours exposure. Hence, the test chemical can be considered to be irritating to skin.